February, 2010
Volume 16, Issue 2

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Volume 16, Issue 2

On pp. 47–57 of this issue, George Tsokos and colleagues present a Feature review on the pathogenesis of human systemic lupus erythematosus (SLE), an autoimmune disease involving multiple organs including the kidneys, joints, nervous system, and hematopoietic organs. The heterogeneity of the disease and lack of adequate tools to diagnose and follow disease progress have been obstacles in the development of effective therapies. The authors discuss the cellular and molecular alterations in the immune system in patients with SLE. Recent findings include the identification of genes associated with disease expression, immune cell dysfunctions that lead to autoimmune pathology, the role of hormones and sex chromosomes in disease development, and environmental and epigenetic factors that might contribute to the expression of SLE. The authors explain how the immune system is broadly compromised in patients with SLE, and that deregulation of specific elements can lead to altered behavior of the whole system. Finally, they discuss the key molecular defects associated with pathogenesis that might represent therapeutic targets and disease biomarkers. Cover image: T cells from SLE patients produce increased amounts of pro-inflammatory cytokines such as IL-17. The image shows T cells from a patient with SLE, stimulated with anti-CD3 and anti-CD28, and stained with anti-IL-17 (green) and nuclear dye DAPI (blue) after permeabilization. Cover image provided by George Tsokos.



Editorial Team

  • Editor
    Amy Donner
  • Executive Editor, Molecular Medicine
    Charlotte Wang

Advisory
Editorial Board

  • S. Agrawal
    K. Alitalo
    H. Blau
    T. Cox
    K. Culver
    K. Davies
    I. Dunham
    F. Gage
    D. Gordon
    W. Günzburg
    D. Gurwitz
    M.A. Liu
    K. Matsushima
    A. McMichael
    A. Papavassiliou
    W. Petri
    D. Rader
    C. Soto
    T. Soussi
    J.S. Stamler
    G.C. Tsokos
    L.-C. Tsui
    J. Uitto
    S. Waxman

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Featured Article

Pathogenesis of human systemic lupus erythematosus: recent advances
José C. Crispín, Stamatis-Nick C. Liossis, Katalin Kis-Toth, Linda A. Lieberman, Vasileios C. Kyttaris, Yuang-Taung Juang, and George C. Tsokos
10.1016/j.molmed.2009.12.005
Abstract | |


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Trends in Molecular Medicine is a leading biomedical review journal, providing reviews and comment on the latest breakthroughs in basic and translational research. This includes basic research aimed at understanding disease mechanisms, and translational research utilizing this information to develop new and improved molecular-targeted approaches for diagnosis, treatment and prevention. Molecular intervention also raises ethical, legal and financial issues. The journal’s objective is to provide a platform for discussion, analysis and debate of these topics across a diverse, multidisciplinary audience of basic scientists and clinicians, who share the common goal of understanding the molecular basis of disease with a view to new clinical practice. Communication of the emerging concepts and ideas will facilitate progress in this exciting and rapidly evolving new field of molecular medicine.

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These are the five most downloaded papers for the 30 days preceding March 10, 2010. See full list of most read articles

Cancer stem cell markers in common cancers – therapeutic implications
Thomas Klonisch, Emilia Wiechec, Sabine Hombach-Klonisch, Sudharsana R. Ande, Sebastian Wesselborg, Klaus Schulze-Osthoff, Marek Los
10.1016/j.molmed.2008.08.003
Summary | |
Anticancer genes: inducers of tumour-specific cell death signalling
Stefan Grimm, Mathieu Noteborn
10.1016/j.molmed.2009.12.002
Summary | |
Induced pluripotent stem cells: current progress and potential for regenerative medicine
Giovanni Amabile, Alexander Meissner
10.1016/j.molmed.2008.12.003
Summary | |
Pathogenesis of human systemic lupus erythematosus: recent advances
José C. Crispín, Stamatis-Nick C. Liossis, Katalin Kis-Toth, Linda A. Lieberman, Vasileios C. Kyttaris, Yuang-Taung Juang, George C. Tsokos
10.1016/j.molmed.2009.12.005
Summary | |
Epigenetics: molecular mechanisms and implications for disease
Adam E. Handel, George C. Ebers, Sreeram V. Ramagopalan
10.1016/j.molmed.2009.11.003
Summary | |