11 March, 2010
Volume 65, Issue 5

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Volume 65, Issue 5

On the cover: The functional organization of the auditory cortex is shaped by auditory experience during developmental critical periods in early life. Though typically adaptive, this developmental bootstrapping process can also be maladaptive if the instructive auditory signals are degraded. In this issue, Popescu and Polley (pp. 718–731) explore how an innocuous and reversible deprivation of acoustic input to one ear affects the development of binaural sound representations in the inferior colliculus and auditory cortex of the rat. Using a combination of auditory brainstem response measurements, unit recordings, and computational modeling, Popescu and Polley determined that monaural deprivation (MD) induced a multifaceted reorganization of binaural response properties that was most pronounced in the auditory cortex of rats receiving MD shortly after the onset of hearing. This age-dependent reorganization of binaural selectivity may help to explain persistent deficits in auditory perceptual acuity observed in individuals with a history of childhood hearing loss.



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