Immunity

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26 February, 2010
Volume 32, Issue 2

Volume 32, Issue 2

On the cover: The spatial organization of immunoreceptors upon ligand binding is a key feature of lymphocyte activation. However, relatively little is known about the steady-state organization and dynamics of immunoreceptors. Treanor et al. (page 187) use high-resolution microscopy to visualize single particles of B cell receptor (BCR; depicted in orange) and components of the membrane skeleton (light blue) simultaneously. Barriers defined by actin and the membrane-cytoskeleton linker protein ezrin restrict diffusion of the BCR. Alteration of the actin cytoskeleton leads to both rapid intracellular signaling as well as transcriptional activation and a concomitant increase in BCR diffusion. Thus, the membrane skeleton plays a critical role in the control of B cell signaling. Image by Lesley McKeane. Preview by Sasaki and Kurosaki (page 143).

One year ago ...

Selected articles from a year ago.

Surh and Sprent discuss how naive and memory T cell homeostasis is regulated.

Flavell and colleagues and Di Santo and colleagues show IL-22 confers protection in the gut.

All archived articles older than one year are available free online.

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Announcing the Inaugural Cell Symposia

Inflammation & Disease

September 26–28, 2010
Lisbon, Portugal
Abstract submission Deadline: May 17, 2010
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Influenza

December 2-4, 2010
Washington, DC
Abstract and Submission Deadline: July 2, 2010
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Online Ahead of Issue

See all new articles.

Identification and Characterization of Enhancers Controlling the Inflammatory Gene Expression Program in Macrophages
Serena Ghisletti, Iros Barozzi, Flore Mietton, Sara Polletti, Francesca De Santa, Elisa Venturini, Lorna Gregory, Lorne Lonie, Adeline Chew, Chia-Lin Wei, Jiannis Ragoussis, and Gioacchino Natoli
Highlights

LPS-inducible binding of p300 to chromatin reveals inflammatory gene enhancers

These enhancers combine sites for tissue-specific and inducible transcription factors

Combination of tissue- and signal-specific TFs adapts the response to the context

Summary | Full Text | PDF

Delivery of Cytosolic Components by Autophagic Adaptor Protein p62 Endows Autophagosomes with Unique Antimicrobial Properties
Marisa Ponpuak, Alexander S. Davis, Esteban A. Roberts, Monica A. Delgado, Christina Dinkins, Zijiang Zhao, Herbert W. Virgin, George B. Kyei, Terje Johansen, Isabelle Vergne, and Vojo Deretic
Highights

Autophagy converts specific cytoplasmic proteins into antimicrobial peptides

Autophagic adaptor p62 delivers Fau and ubiquitinated complexes to autolysosomes

Ribosomal proteins and ubiquitin are digested by lysosomal hydrolases in autolysosomes

Conversion of cytoplasmic proteins into bactericidal peptides kills M. tuberculosis

Summary | Full Text | PDF

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Current Issue

Fas Doubles as a Navigator

Article by Martin-Villalba and colleagues. Preview by Constantin and Laudanna.

On the cover: Actin control of B cell receptor dynamics
Article by Batista and colleagues. Preview by Sasaki and Kurosaki.

Next issue: March 26, 2010

Also In This Issue

Killing the Messenger

Tumor cells have generated clever ways to escape immune detection including the ability to recruit Treg cells to aid in this process. Using dynamic imaging intravital microscopy, Amigorena and colleagues find that Treg cells can directly kill dendritic cells presenting a model tumor antigen in vivo.

Tonic stimulation

Maintaining CD8⁺ T cell homeostasis requires tonic signaling through the T cell receptor. Sprent and colleagues show that tonic signaling through recognition of self antigen, upregulates expression of lipid raft components to which IL-2 receptors are recruited. Preview by Stone and Kranz.

Confinement time

T cell activation by an MHC-peptide ligand is attributed to a combination of on rate, affinity, and half life of the receptor ligand interaction. van der Merwe and colleagues demonstrate a “confinement time” model that more effectively explains the role of T cell receptor-pMHC binding kinetics and affinity in T cell activation. Preview by Govern and Chakraborty.

Resource: Dendritic cell subset protein signature

Mann and colleagues used high resolution mass spectrometry-based proteomics and unique algorithm for label-free quantitation to study proteins in different dendritic cell (DC) subsets including plasmacytoid DC and subsets of conventional DC. Preview by Buschow and Figdor.