16 February, 2010
Volume 18, Issue 2

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Volume 18, Issue 2

On the cover: The cover image of Arabidopsis thaliana in flower was processed using Photoshop's glowing edges filter (credit: Alexander Simpson). In this issue, a regulator of flowering time, FPA, is shown to control RNA cleavage and alternative polyadenylation. This function affects antisense RNAs at the FLC locus; at other sites, defective RNA 3′ end formation in the absence of FPA can result in readthrough transcription of silenced loci. For details, see Hornyik et al., pp. 203–213, and the Preview by Rosonina and Manley, pp. 172–174.

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Making the Most of Online Article Presentation

This is the second issue presented in our new "Article of the Future" format. Last month, Marc Bühler contributed an author audio clip on Dicer nucleocytoplasmic shuttling. This month, there are more graphical abstracts, and a second author audio clip in which David Doupé and Phil Jones explain how their paper relates to previous work on progenitor division and cell fate in the mouse epidermis.

The articles in this issue also follow our new guidelines for supplemental material. Learn more about the rationale behind them in a Cell editorial from last year.

Please take advantage of this month's free access to explore the "Article of the Future" format and how it changes online navigation of research papers.

And tell us what you think!


Immediate Early Publication

RNF8-Dependent Histone Modifications Regulate Nucleosome Removal during Spermatogenesis
Lin-Yu Lu, Jiaxue Wu, Lin Ye, Galina B. Gavrilina, Thomas L. Saunders, and Xiaochun Yu
10.1016/j.devcel.2010.01.010
Summary | Full Text | PDF

In the February Issue

Review Series

Our series of organogenesis reviews continues in this issue with a contribution from Stephen Duncan’s group, on the development, structure, and function of the liver. For this and other recent Dev Cell review series, please see our collection on this page.

Issue Highlights

Kernohan et al.find that the chromatin proteins implicated in three distinct cognitive developmental disorders interact in the mouse brain. One protein (ATRX) helps recruit others (e.g., MeCP2, CTCF, and cohesin) to control the silencing of an imprinted gene network in neonates.
Zeng et al. reveal the atypical GTPase domain of the SCF ubiquitin ligase adaptor Fbx4, bound to a substrate globular domain rather than the usual short degron. Their work also shows how telomere shelterin protein levels are tuned by Fbx4 interactions.
Tian et al. elucidate the role of Wnt2 in atrial myocardial and cardiac inflow tract development. Cardiac defects in Wnt2 mice resemble those seen in the human congenital heart syndrome CCAVC and, notably, can be rescued with drugs that activate the Wnt pathway.
Also in this issue:
Alternative polyadenylation, flowering time, and antisense RNA
PI3K and Rac: live-imaging neutrophil migration in vivo
Coordinated assembly of the ciliary axoneme and membrane
Kinetochore microtubules seek out the mitotic spindle
Modeling BMP pathways: capitalizing on spatiotemporal detail
KIBRA scaffolds the Hippo pathway (Yu et al., Genevet et al., and Baumgartner et al.)
Random progenitor division and fate in the mouse epidermis
Resource: Knocking out by "knocking sideways"

Click here for the complete table of contents.

Featured Topic

A selection of recent Developmental Cell on the protease-mediated signaling in development and disease. For previous featured topics, click here.

Local Protease Signaling Contributes to Neural Tube Closure in the Mouse Embryo
Eric Camerer, Adrian Barker, Daniel N. Duong, Rajkumar Ganesan, Hiroshi Kataoka, Ivo Cornelissen, Molly R. Darragh, Arif Hussain, Yao-Wu Zheng, Yoga Srinivasan, Christopher Brown, Shan-Mei Xu, Jean B. Regard, Chen-Yong Lin, Charles S. Craik, Daniel Kirchhofer, Shaun R. Coughlin

MT1-MMP Is Required for Myeloid Cell Fusion via Regulation of Rac1 Signaling
Pilar Gonzalo, Marta C. Guadamillas, María Victoria Hernández-Riquer, Ángela Pollán, Araceli Grande-García, Rubén A. Bartolomé, Amit Vasanji, Chiara Ambrogio, Roberto Chiarle, Joaquín Teixidó, Juha Risteli, Suneel S. Apte, Miguel A. del Pozo, Alicia G. Arroyo

ADAMTS Metalloproteases Generate Active Versican Fragments that Regulate Interdigital Web Regression
Daniel R. McCulloch, Courtney M. Nelson, Laura J. Dixon, Debra L. Silver, James D. Wylie, Volkhard Lindner, Takako Sasaki, Marion A. Cooley, W. Scott Argraves, Suneel S. Apte

MT2-MMP-Dependent Release of Collagen IV NC1 Domains Regulates Submandibular Gland Branching Morphogenesis
Ivan T. Rebustini, Christopher Myers, Keyonica S. Lassiter, Andrew Surmak, Ludmila Szabova, Kenn Holmbeck, Vadim Pedchenko, Billy G. Hudson, Matthew P. Hoffman

Spatial Restriction of FGF Signaling by a Matrix Metalloprotease Controls Branching Morphogenesis
Qiong Wang, Mirka Uhlirova, Dirk Bohmann

And from Trends journals:

Trends in Biotechnology
Caspase substrates: easily caught in deep waters?
Dieter Demon, Petra Van Damme, Tom Vanden Berghe, Joël Vandekerckhove, Wim Declercq, Kris Gevaert, Peter Vandenabeele

Trends in Microbiology
Killing me softly: chlamydial use of proteolysis for evading host defenses
Guangming Zhong

Trends in Parasitology
The global cysteine peptidase landscape in parasites
Holly J. Atkinson, Patricia C. Babbitt, Mohammed Sajid

Trends in Pharmological Sciences
Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease?
Roger Yazbeck, Gordon S. Howarth, Catherine A. Abbott