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Volume 140, Issue 5

On the cover: Host genetic differences can be important determinants of tuberculosis susceptibility and outcome. In this issue, Tobin et al. (pp. 717–730) use a forward genetic screen in the zebrafish to show that mutations in the lta4h gene confer hypersusceptibility to mycobacterial infection by altering the balance of pro- and anti-inflammatory signaling molecules. In humans, heterozygosity at the LTA4H locus confers protection from two mycobacterial diseases, tuberculosis and leprosy. The cover image highlights the River Ganges, where the zebrafish originated, and the countries of Nepal and Vietnam, where the human genetic studies described in this paper were carried out. Illustration by John Ray.

Articles in Other Cell Press Journals

Cell Stem Cell
SIP1 Mediates Cell-Fate Decisions between Neuroectoderm and Mesendoderm in Human Pluripotent Stem Cells
Zhenzhi Chng, Adrian Teo, Roger A. Pedersen, Ludovic Vallier
Summary | Full Text | PDF (1769 kb)
Neuron
Manipulation of a Central Auditory Representation Shapes Learned Vocal Output
Huimeng Lei, Richard Mooney
Summary | Full Text | PDF (1449 kb)
Developmental Cell
Nuclear Retention of Fission Yeast Dicer Is a Prerequisite for RNAi-Mediated Heterochromatin Assembly
Stephan Emmerth, Heiko Schober, Dimos Gaidatzis, Tim Roloff, Kirsten Jacobeit, Marc Bühler
Summary | Full Text | PDF (1746 kb)
Cell Host & Microbe
A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria
Rachel D. Hood, Pragya Singh, FoSheng Hsu, Tüzün Güvener, Mike A. Carl, Rex R.S. Trinidad, Julie M. Silverman, Brooks B. Ohlson, Kevin G. Hicks, Rachael L. Plemel, Mo Li, Sandra Schwarz, Wenzhuo Y. Wang, Alexey J. Merz, David R. Goodlett, Joseph D. Mougous
Summary | Full Text | PDF (1025 kb)

Leading Edge

In This Issue p591
Full Text | PDF (254 kb)
Genetics Select p595
Summary | Full Text | PDF (733 kb)

Essay

Membrane Curvature in Synaptic Vesicle Fusion and Beyond p601
Harvey T. McMahon, Michael M. Kozlov, Sascha Martens
Summary | Full Text | PDF (827 kb)

Previews

The Incredible Expanding Ancestor of Eukaryotes p606
Eugene V. Koonin
Summary | Full Text | PDF (508 kb)
Angelman Syndrome: Finding the Lost Arc p608
Hwan-Ching Tai, Erin M. Schuman
Summary | Full Text | PDF (342 kb)
A Penetrating Look at Stochasticity in Development p610
Robert J. Johnston, Claude Desplan
Summary | Full Text | PDF (330 kb)
MicroRNAs: From Decay to Decoy p612
Michaela Beitzinger, Gunter Meister
Summary | Full Text | PDF (309 kb)

Minireview

TB: Screening for Responses to a Vile Visitor p615
Marcel Behr, Erwin Schurr, Philippe Gros
Summary | Full Text | PDF (803 kb)

Review

Featured ArticleFree
Autoimmunity and the Clearance of Dead Cells p619
Shigekazu Nagata, Rikinari Hanayama, Kohki Kawane
Summary | Full Text | PDF (1491 kb)

Articles

Featured ArticleFree
The Genome of Naegleria gruberi Illuminates Early Eukaryotic Versatility p631
Lillian K. Fritz-Laylin, Simon E. Prochnik, Michael L. Ginger, Joel B. Dacks, Meredith L. Carpenter, Mark C. Field, Alan Kuo, Alex Paredez, Jarrod Chapman, Jonathan Pham, Shengqiang Shu, Rochak Neupane, Michael Cipriano, Joel Mancuso, Hank Tu, Asaf Salamov, Erika Lindquist, Harris Shapiro, Susan Lucas, Igor V. Grigoriev, W. Zacheus Cande, Chandler Fulton, Daniel S. Rokhsar, Scott C. Dawson
Summary | Full Text
Protein Dynamics in Drug Combinations: a Linear Superposition of Individual-Drug Responses p643
Naama Geva-Zatorsky, Erez Dekel, Ariel A. Cohen, Tamar Danon, Lydia Cohen, Uri Alon
Summary | Full Text
miR-328 Functions as an RNA Decoy to Modulate hnRNP E2 Regulation of mRNA Translation in Leukemic Blasts p652
Anna M. Eiring, Jason G. Harb, Paolo Neviani, Christopher Garton, Joshua J. Oaks, Riccardo Spizzo, Shujun Liu, Sebastian Schwind, Ramasamy Santhanam, Christopher J. Hickey, Heiko Becker, Jason C. Chandler, Raul Andino, Jorge Cortes, Peter Hokland, Claudia S. Huettner, Ravi Bhatia, Denis C. Roy, Stephen A. Liebhaber, Michael A. Caligiuri, Guido Marcucci, Ramiro Garzon, Carlo M. Croce, George A. Calin, Danilo Perrotti
Summary | Full Text
Stc1: A Critical Link between RNAi and Chromatin Modification Required for Heterochromatin Integrity p666
Elizabeth H. Bayne, Sharon A. White, Alexander Kagansky, Dominika A. Bijos, Luis Sanchez-Pulido, Kwang-Lae Hoe, Dong-Uk Kim, Han-Oh Park, Chris P. Ponting, Juri Rappsilber, Robin C. Allshire
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Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions p678
Aaron D. Goldberg, Laura A. Banaszynski, Kyung-Min Noh, Peter W. Lewis, Simon J. Elsaesser, Sonja Stadler, Scott Dewell, Martin Law, Xingyi Guo, Xuan Li, Duancheng Wen, Ariane Chapgier, Russell C. DeKelver, Jeffrey C. Miller, Ya-Li Lee, Elizabeth A. Boydston, Michael C. Holmes, Philip D. Gregory, John M. Greally, Shahin Rafii, Chingwen Yang, Peter J. Scambler, David Garrick, Richard J. Gibbons, Douglas R. Higgs, Ileana M. Cristea, Fyodor D. Urnov, Deyou Zheng, C. David Allis
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The Tetrahymena Argonaute-Binding Protein Giw1p Directs a Mature Argonaute-siRNA Complex to the Nucleus p692
Tomoko Noto, Henriette M. Kurth, Kensuke Kataoka, Lucia Aronica, Leroi V. DeSouza, K.W. Michael Siu, Ronald E. Pearlman, Martin A. Gorovsky, Kazufumi Mochizuki
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The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc p704
Paul L. Greer, Rikinari Hanayama, Brenda L. Bloodgood, Alan R. Mardinly, David M. Lipton, Steven W. Flavell, Tae-Kyung Kim, Eric C. Griffith, Zachary Waldon, Rene Maehr, Hidde L. Ploegh, Shoaib Chowdhury, Paul F. Worley, Judith Steen, Michael E. Greenberg
Summary | Full Text
The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans p717
David M. Tobin, Jay C. Vary, John P. Ray, Gregory S. Walsh, Sarah J. Dunstan, Nguyen D. Bang, Deanna A. Hagge, Saraswoti Khadge, Mary-Claire King, Thomas R. Hawn, Cecilia B. Moens, Lalita Ramakrishnan
Summary | Full Text

Resources

Genome-wide Analysis of the Host Intracellular Network that Regulates Survival of Mycobacterium tuberculosis p731
Dhiraj Kumar, Lekha Nath, Md. Azhar Kamal, Ankur Varshney, Avinash Jain, Sarman Singh, Kanury V.S. Rao
Summary | Full Text
An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man p744
Timothy Ravasi, Harukazu Suzuki, Carlo Vittorio Cannistraci, Shintaro Katayama, Vladimir B. Bajic, Kai Tan, Altuna Akalin, Sebastian Schmeier, Mutsumi Kanamori-Katayama, Nicolas Bertin, Piero Carninci, Carsten O. Daub, Alistair R.R. Forrest, Julian Gough, Sean Grimmond, Jung-Hoon Han, Takehiro Hashimoto, Winston Hide, Oliver Hofmann, Hideya Kawaji, Atsutaka Kubosaki, Timo Lassmann, Erik van Nimwegen, Chihiro Ogawa, Rohan D. Teasdale, Jesper Tegnér, Boris Lenhard, Sarah A. Teichmann, Takahiro Arakawa, Noriko Ninomiya, Kayoko Murakami, Michihira Tagami, Shiro Fukuda, Kengo Imamura, Chikatoshi Kai, Ryoko Ishihara, Yayoi Kitazume, Jun Kawai, David A. Hume, Trey Ideker, Yoshihide Hayashizaki
Summary | Full Text

Addendum

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice p753
Ehud Cohen, Johan F. Paulsson, Pablo Blinder, Tal Burstyn-Cohen, Deguo Du, Gabriela Estepa, Anthony Adame, Hang M. Pham, Martin Holzenberger, Jeffery W. Kelly, Eliezer Masliah, Andrew Dillin
Full Text | PDF (33 kb)

SnapShot

SnapShot: Nucleotide Excision Repair p754
Caixia Guo, Tie-Shan Tang, Errol C. Friedberg
PDF (1334 kb)