Journals
18 February, 2010
Volume 7, Issue 2
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Volume 7, Issue 2
On the cover: Autophagy clears damaged or unwanted cellular proteins and organelles through lysosomal degradation to prevent their toxic accumulation. In this issue, Orvedahl et al. (pp. 115–127) show that autophagy may also target viral proteins to promote cell survival during infection. Depicted on the cover is a model where Sindbis virus capsid particles (red) are linked by the autophagic adaptor p62 (blue) to LC3 (green) in the autophagosomal membrane. Artwork by Elizabeth C. Smith (UT Southwestern Medical Center at Dallas).
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Featured Topic:
Bacteria and Immune Homeostasis
A balanced host immune response is actively established and maintained - with bacteria playing a key role.
Mammalian tolerance
of microbiota
IgA Response to Symbiotic Bacteria as a Mediator of Gut Homeostasis
Zebrafish tolerance
of microbiota
Mammalian tolerance
of lipopolysaccharide
Drosophila tolerance
of microbiota
PIMS Modulates Immune Tolerance by Negatively Regulating Drosophila Innate Immune Signaling
Drosophila tolerance
of microbiota
Peptidoglycan recognition
and arthritis
PGLYRP-2 and Nod2 Are Both Required for Peptidoglycan-Induced Arthritis and Local Inflammation
Drosophila tolerance
of peptidoglycan
Microbiota promote
resistance to Toxoplasma
Gut Commensal Bacteria Direct a Protective Immune Response against Toxoplasma gondii
Microbiota and
immune development
Microbiota and
immune development
Bacteria-induced
autoimmunity
Liver Autoimmunity Triggered by Microbial Activation of Natural Killer T Cells
Bacteria and
intestinal inflammation
Commensals, Bacterial Pathogens and Intestinal Inflammation: An Intriguing Ménage à Trois (Review)
Microbiota in
inflammatory bowel disease
Metagenomic Approaches for Defining the Pathogenesis of Inflammatory Bowel Diseases (Review)
Announcing the Inaugural Cell Symposia
Inflammation & Disease
September 26-28, 2010
Lisbon, Portugal
Abstract submission deadline: May 17, 2010
Register Now! Submit Your Abstract
Influenza
December 2-4
Washington, DC
Abstract submission deadline: July 2, 2010
Register Now! Submit Your Abstract
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New Online Article Presentation
We are excited to feature our second issue in the "Article of the Future" format, which gives readers a new way to explore our research papers online. Among many added features, each paper has Highlights summarizing its main message, and authors also have the opportunity to include a Graphical Abstract like the one from Jamieson and colleagues.
In the February Issue
Influenza Virus-Induced Glucocorticoids and Immunosuppressiona
Autophagic Viral Protein Clearance in Antiviral DefenseaPreview
Antibody Dependent Enhancement of Dengue Disease in MiceaPreview
Microbiota Regulate IL-17 Producing γ/δ T cells
GM-CSF in Intestinal Mucosal Defense to an Enteric Pathogen
Plant Signaling Pathway Activated by P. syringae AvrB
Review: Metabolomics of Host-Parasite Interactions
Click here for the complete table of contents.
Next issue: March 18, 2010
Featured Articles
Featured Articles are freely available to all readers.
 |
Jaimeson et al. find that influenza virus infection triggers a generalized stress response leading to glucocorticoid induction, systemic immune suppression, and increased burden of a coinfecting systemic bacterial pathogen. |
 |
Orvedahl et al. demonstrate that autophagy protects mice against lethal Sindbis virus CNS infection by degrading viral proteins whose accumulation would otherwise cause neuronal cell death. Preview by Yoshimori. |
 |
Zellweger et al. describe a murine model of antibody-enhanced dengue virus infection and disease providing formal proof that a subprotective humoral response may have pathological consequences. Preview by Pierson. |
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Host-Microbe Papers in Other Cell Press Journals
Immunity, January 2010
Distinct Melanization Pathways in the Mosquito Aedes aegypti
Zhen Zou, Sang Woon Shin, Kanwal S. Alvarez, Vladimir Kokoza, Alexander S. Raikhel
Molecular Cell, January 2010
Caspase-Mediated Cleavage, IAP Binding, and Ubiquitination: Linking Three Mechanisms Crucial for Drosophila NF-κB Signaling
Nicholas Paquette, Meike Broemer, Kamna Aggarwal, Li Chen, Marie Husson, Deniz Ertürk-Hasdemir, Jean-Marc Reichhart, Pascal Meier, Neal Silverman
Molecular Cell, February 2010
Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced Mutagenesis
Michael A. Kohanski, Mark A. DePristo, James J. Collins
Cell, February 2010
RIG-I Detects Viral Genomic RNA during Negative-Strand RNA Virus Infection
Jan Rehwinkel, Choon Ping Tan, Delphine Goubau, Oliver Schulz, Andreas Pichlmair, Katja Bier, Nicole Robb, Frank Vreede, Wendy Barclay, Ervin Fodor, Caetano Reis e Sousa
