Journals
17 February, 2010
Volume 17, Issue 2
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Volume 17, Issue 2
On the cover: An enlarged micrograph shows colonies grown from MLL-AF9-transformed bone marrow. Thiel et al. have uncovered that wild-type MLL allele is required for maintenance of MLL-AF9-transformed bone marrow colonies and leukemia cells and MLL-AF9-induced leukemogenesis. Image by Austin Thiel.
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Volume 17 Issue 2: February 15, 2010
Featured Article
Featured articles are freely available to all readers
A Higher-Order Complex Containing AF4- and ENL-Family Proteins with P-TEFb Facilitates Oncogenic and Physiologic MLL-Dependent Transcription
Akihiko Yokoyama, Min Lin, Alpana Naresh, Issay Kitabayashi, and Michael L. Cleary
AF4 and ENL family proteins are frequently fused with MLL, and they comprise a higher order complex (designated AEP) containing the P-TEFb transcription elongation factor. Here, we show that AEP is normally recruited to MLL-target chromatin to facilitate transcription. In contrast, MLL oncoproteins fused with AEP components constitutively form MLL/AEP hybrid complexes to cause sustained target gene expression, which leads to transformation of hematopoietic progenitors. Furthermore, MLL-AF6, an MLL fusion with a cytoplasmic protein, does not form such hybrid complexes, but nevertheless constitutively recruits AEP to target chromatin via unknown alternative mechanisms. Thus, AEP recruitment is an integral part of both physiological and pathological MLL-dependent transcriptional pathways. Bypass of its normal recruitment mechanisms is the strategy most frequently used by MLL oncoproteins.
Immediate Electronic Publication
The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting a-Ketoglutarate to 2-Hydroxyglutarate
Patrick S. Ward, Jay Patel, David R. Wise, Omar Abdel-Wahab, Bryson D. Bennett, Hilary A. Coller, Justin R. Cross, Valeria R. Fantin, Cyrus V. Hedvat, Alexander E. Perl, Joshua D. Rabinowitz, Martin Carroll, Shinsan M. Su, Kim A. Sharp, Ross L. Levine, and Craig B. Thompson
Summary | Full Text | PDF
On the Cover
An enlarged micrograph shows colonies grown from MLL-AF9-transformed bone marrow. Thiel et al. have uncovered that wild-type MLL allele is required for maintenance of MLL-AF9-transformed bone marrow colonies and leukemia cells and MLL-AF9-induced leukemogenesis. Image by Austin Thiel.
Next issue : March 16, 2010
Cell Press Podcast
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You can listen directly by clicking on the player above. For a complete list of Cell Press podcasts, view the archive. |
In our February podcast, we hear from Mike Cleary about how MLL fusion proteins contribute to leukemogenesis (starts at 16:21). We also hear from Colin Renfrew about the earliest journeys of our ancestors revealed by archaeogenetics (0:50) and from Bob Roeder about a versatile transcription elongation factor with several key functions in the cell (11:12).
